SnapShot: Ion Channels and Pain
نویسنده
چکیده
Nav1.3 TTX-sensitive, voltagegated sodium channel Embryonic DRG and TG neurons, spinal cord, and thalamus; upregulated in DRG and dorsal horn neurons following nerve injury Loss of function attenuates pain-related behavior Na+ channel blockers including local anesthetics, anticonvulsants, antiarrhythmic, and TCAs relieve pain associated with neuropathy, diabetes, osteoarthritis, and surgery. Mutations in the Nav1.7 gene (scn9a) cause erythromelalgia and paroxysmal extreme pain disorder; loss of function of Nav1.7 results in pain insensitivity. Nav1.7 TTX-sensitive, voltagegated sodium channel Most adult DRG and TG neurons; upregulated in small DRG and TG neurons postinflammation Loss of function reduces mechanical and thermal hypersensitivity; the Nav1.7/Nav1.8 blocker CDA54 reduces neuropathic pain in nerve injury models
منابع مشابه
Simulation study of the transport properties of ions through ion channels serving as primary components of a nanobiosensor
Ion channels are naturally occurring pores through the proteins that regulate the passage of ions and thus maintain the concentration of ions inside and outside the cell. The ion channels control many physiological functions and they can show selectivity for a specific ion. Ion channels are mostly observed in nerve cells and muscle cells. The influx of ions into cells can be regulated by a gate...
متن کاملSimulation study of the transport properties of ions through ion channels serving as primary components of a nanobiosensor
Ion channels are naturally occurring pores through the proteins that regulate the passage of ions and thus maintain the concentration of ions inside and outside the cell. The ion channels control many physiological functions and they can show selectivity for a specific ion. Ion channels are mostly observed in nerve cells and muscle cells. The influx of ions into cells can be regulated by a gate...
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ورودعنوان ژورنال:
- Cell
دوره 134 شماره
صفحات -
تاریخ انتشار 2008